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This volume summarizes the proceedings of two workshops sponsored by the Bill and Melinda Gates Foundation on cutting edge systems and synthetic biology research which could facilitate mitigation and adaptation through quantum leaps in photosynthesis, fertilization, methane control, and drought and disease resistance, and thereby substantially increase crop yield and soil carbon. The technologies are at various stages of development--some are ...

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This book is about the history of emerging new therapies and preventions for a host of human diseases via biotechnology, the science that drives it and the people and companies who transformed that science into the biotechnologies we benefit from"--

The laboratory mouse is an important model in biomedical research. This volume provides the concepts and tools needed to generate mutant mice and analyze their phenotypes"--

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The retina is a layer of neural tissue that lines the inner eye and captures visual stimuli. This volume provides an update on retinal diseases, describing the genetic and pathophysiological basis of the diseases and advances in strategies to treat them"--

Written and edited by experts in the field, this collection provides a comprehensive update on advances in our understanding of the structure and multiple functions of the ER. The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. In addition, they discuss how lipids are synthesized and transported to and from the ER.

There are thousands of diseases classed as "rare" because they afflict only a small number of people. These patient groups were long ignored by a pharmaceutical industry that judged them too small to provide a return on the investment needed to develop an effective remedy. Forty years ago, a revolution started that transformed the prospects of patients with rare diseases. This book is in part a history, with eyewitness accounts of advances as ...

This book reviews our current understanding of the cellular, molecular, and biophysical mechanisms involved in skin wound healing, as well as the function and regulation of different skin cell types, including epithelial cells, fibroblasts, immune cells, neural cells, and endothelial cells.

Written and edited by experts in the field, this collection summarizes recent progress in this area. It includes contributions covering epigenetic mechanisms in the brain, neuroendocrine responses to stress, and the evolution of reversed sex differences in the behavior of spotted hyenas, as well as studies of how sex differences may affect circadian rhythms, immune disorders, and depression.

Written and edited by experts in the field, this collection from explores the biological basis of regeneration in diverse animal species and how this knowledge can be applied therapeutically in humans. The contributors discuss the dramatic molecular and cellular changes that occur when a regeneration program is initiated, the progenitor cells and morphogenic signals involved, the formation of a blastema, the roles of reprogramming and polyploi...

Essentials of Glycobiology is the field's most authoritative textbook, offering an overview suitable for advanced undergraduates and graduate students in molecular and cellular biology and biomedicine. In an entirely revised and updated fourth edition, the book retains a broad focus and applicability to fields ranging from biology and medicine to chemistry and materials science, with excellent artwork and chapters written by an international s...

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Gene Transfer: Delivery and Expression of DNA and RNA provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression.

The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes.